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KPV
A tripeptide fragment studied for its role in inflammatory pathway research. Compact, precise, and increasingly relevant in gut and skin biology research models.
$40.00
- +99% Purity
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A tripeptide fragment studied for its role in inflammatory pathway research. Compact, precise, and increasingly relevant in gut and skin biology research models.
About KPV
KPV, lysine-proline-valine, is a tripeptide fragment derived from the C-terminal end of alpha-MSH, a naturally occurring hormone investigated for its role in regulating inflammatory signaling pathways. While alpha-MSH itself is a larger molecule with a broad range of biological activity, researchers identified that much of its anti-inflammatory signaling effect could be attributed to the KPV sequence at its tail end. This finding made KPV a subject of focused research interest as a smaller, more targeted compound for studying inflammation-related signaling processes in controlled research settings.
The compound’s primary research profile centers on its ability to modulate inflammatory signaling activity in tissue research models. Inflammation is a necessary biological process, but when it becomes chronic or dysregulated in research models, it has been associated with a range of tissue damage signaling outcomes including barrier breakdown, impaired wound healing pathway activity, and accelerated cellular aging markers. KPV has been studied for its potential to interrupt these inflammatory signals at the pathway level before measurable tissue changes occur, making it relevant to investigators across dermatological, gastrointestinal, and regenerative research contexts.
A particularly active area of KPV research involves the gut-skin axis. Studies have examined KPV’s potential to strengthen intestinal barrier signaling and reduce the passage of inflammatory molecules into systemic circulation in laboratory research models. Researchers have investigated whether compounds capable of modulating gut-derived inflammatory pathway activity produce measurable downstream effects on skin barrier signaling, positioning KPV as a systemically relevant research subject beyond its direct tissue-level signaling activity in vitro.
Mechanism of Action
- KPV has been studied for its ability to reduce the production of pro-inflammatory signaling molecules in intestinal and dermal tissue research models. Research has examined how suppressing these signals at the pathway level may reduce the chronic low-grade inflammatory activity associated with barrier breakdown and impaired tissue repair signaling in controlled research settings.
- Studies have investigated KPV’s effects on intestinal barrier integrity in vitro. The gut barrier regulates what passes from the digestive tract into systemic circulation, and research has examined whether KPV helps maintain or restore this barrier function at the cellular level, reducing the downstream inflammatory signaling load that reaches distant tissue research models.
- KPV has been researched for its direct effects on dermal tissue inflammatory signaling. Studies have examined its potential to reduce inflammatory markers in dermal tissue research models, with investigators studying whether this activity influences barrier function and tissue repair pathway organization in experimental research settings.
- Research has investigated KPV’s role in wound healing pathway activity in inflamed tissue research environments. Studies have examined whether its anti-inflammatory signaling activity supports more organized tissue repair in models where chronic inflammatory pathway dysregulation would otherwise impair repair signaling processes in vitro.
- KPV has been studied for its potential to modulate immune cell signaling activity at sites of tissue inflammation, with research examining whether reducing immune-driven inflammatory pathway activity leads to measurable changes in tissue damage markers in preclinical research models.
Research Highlights
KPV has been studied in inflammatory bowel research models for its potential to modulate gut inflammatory signaling and support intestinal barrier integrity at the cellular level. Research has examined its effects on tight junction protein activity in vitro, with studies reporting changes in permeability markers and inflammatory signaling levels in KPV-treated research models.
KPV has been investigated in dermal research models relevant to inflammatory skin signaling pathways. Studies have examined its potential to reduce pro-inflammatory signal production in skin tissue research models, with investigators studying whether this activity influences barrier integrity and tissue damage markers in experimental research settings.
Research has examined KPV's potential to support wound healing pathway activity in tissue research environments characterized by elevated inflammatory signaling. Studies have investigated whether its anti-inflammatory pathway activity supports more organized repair processes in inflamed research models compared to controls in controlled laboratory settings.
KPV has been studied for its ability to modulate inflammatory signaling markers across multiple tissue types in structured research environments. Research has examined its anti-inflammatory pathway activity in both localized and systemic research contexts, with investigators studying its relevance to models where chronic low-grade inflammatory signaling drives progressive tissue damage markers over time.
Product Specifications
- Molecular Formula
- C₁₅H₂₉N₃O₄
- Molecular Weight
- 315.41 g/mol
- CAS #
- 67727-97-3
- Sequence
- Lys-Pro-Val
- Purity
- ≥99% (HPLC verified)
- Form
- Lyophilized powder
- Appearance
- White to off-white powder
- Solubility
- Universal Solvent
- Storage
- -20°C (lyophilized), 2-8°C (after preparation)
Reference
- Brzoska, T., Luger, T. A., Maaser, C., Abels, C., & Böhm, M. (2008). Alpha-melanocyte-stimulating hormone and related tripeptides: Biochemistry, antiinflammatory and protective effects in vitro and in vivo. Endocrine Reviews, 29(5), 581–602.
- Kannengiesser, K., Maaser, C., Heidemann, J., et al. (2008). Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflammatory Bowel Diseases, 14(3), 324–331.
- Catania, A., Lonati, C., Sordi, A., Carlin, A., Leonardi, P., & Gatti, S. (2010). The melanocortin system in control of inflammation. Scientific World Journal, 10, 1840–1853.
