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Epithalon
A synthetic tetrapeptide investigated for its interactions with telomerase activity and pineal gland function. Among the most studied compounds in longevity and cellular aging research models.
$150.00
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A synthetic tetrapeptide investigated for its interactions with telomerase activity and pineal gland function. Among the most studied compounds in longevity and cellular aging research models.
About Epithalon
Epithalon, with the amino acid sequence Ala-Glu-Asp-Gly, was developed from research into epithalamin, a peptide extract isolated from pineal gland tissue research models. The pineal gland plays a central role in regulating circadian rhythms through melatonin production, and researchers investigating the biological effects of pineal peptides identified epithalamin as a compound with apparent influence on aging-related signaling processes. Epithalon was synthesized as a defined, reproducible version of this active sequence for use in controlled laboratory research settings.
The compound’s most discussed area of study involves its potential effects on telomeres, the protective caps at the ends of chromosomes that shorten each time a cell divides. Telomere shortening is widely studied as a marker and potential driver of cellular aging at the molecular level, and research has examined Epithalon’s potential to activate telomerase, the enzyme responsible for maintaining and rebuilding telomere length. This activity would place Epithalon among a very small group of compounds studied for their potential to directly influence one of the core proposed mechanisms of biological aging in controlled research settings.
Beyond telomere research, Epithalon has been studied for its effects on pineal gland regulatory signaling, particularly melatonin synthesis pathway activity. Melatonin production declines in aging research models, a change that has been associated in research with disrupted circadian signaling, reduced antioxidant pathway activity, and shifts in immune function markers. Studies have examined whether Epithalon supports pineal activity in aged research models and whether that support produces measurable changes in melatonin output and related biological markers in vitro.
Mechanism of Action
- Telomerase Activation: Epithalon has been studied for its potential to activate telomerase, the enzyme that rebuilds the protective caps at the ends of chromosomes. Telomeres shorten each time a cell divides, and their progressive shortening is studied as one of the primary markers of cellular aging at the molecular level. Research has examined whether Epithalon-driven telomerase activation leads to measurable telomere lengthening in aged cell research models.
- Pineal Gland and Melatonin Signaling: Studies have investigated Epithalon’s effects on pineal gland signaling, with research examining its potential to support melatonin production in aged tissue research models. Melatonin functions as both a circadian regulator and an antioxidant signaling molecule, and researchers have studied whether Epithalon’s pineal activity produces measurable changes in circadian regulation and oxidative stress markers in controlled research settings.
- Antioxidant Pathway Activity: Epithalon has been researched for its antioxidant signaling properties, with studies examining its potential to reduce oxidative stress markers in aging tissue research models. Oxidative stress, the accumulation of damaging molecules produced during normal cellular activity, is studied as a key driver of tissue aging and cellular dysfunction at the molecular level, and researchers have investigated whether Epithalon modulates this process in vitro.
- Immune Signaling Modulation: Research has examined Epithalon’s effects on immune signaling function in aged research models, with studies investigating its potential to support immune cell activity that declines in aging signaling contexts. Investigators have studied whether these immune-modulatory signaling effects contribute to the broader changes in biological markers observed in Epithalon-treated research models.
- Hormone Regulation Research: Epithalon has been studied for its influence on hormone regulation, with research examining its effects on growth hormone and cortisol signaling levels in aged research models. Both hormones shift significantly in aging signaling contexts, and investigators have studied whether Epithalon’s pineal and neuroendocrine pathway activity contributes to measurable changes in hormonal signaling profiles in controlled research settings.
Research Highlights
Epithalon's most distinctive research profile involves its studied effects on telomere length and telomerase activity, placing it among a very small group of compounds investigated for direct interaction with one of the core proposed mechanisms of cellular aging. Research conducted in cell culture research models has examined its potential to activate telomerase and produce measurable changes in telomere length in aged cell research settings, with investigators studying this activity as a potential mechanism by which Epithalon may influence the rate of cellular aging signaling at the molecular level.
Studies have examined Epithalon's effects on pineal gland signaling and melatonin output in aged research models, with research reporting measurable changes in melatonin production in treated models compared to controls. Given melatonin's dual role as a circadian regulator and antioxidant signaling molecule, this research connects Epithalon to both aging biology and oxidative stress pathway activity in controlled research environments.
Epithalon has been studied for its ability to reduce oxidative stress markers in aging tissue research models, with research examining its effects on oxidative damage accumulation and antioxidant signaling system activity. Investigators have studied this antioxidant pathway activity as a potential contributor to the broader longevity-related signaling changes observed in longer-term Epithalon research models.
Some of the most closely followed Epithalon research involves its studied effects on lifespan-related signaling markers in preclinical research models. Studies conducted over extended periods have examined changes in mean and maximum lifespan markers in Epithalon-treated research models compared to controls, with investigators attributing these findings to the compound's combined effects on telomere biology, oxidative stress signaling, immune function, and hormonal regulation pathway activity in structured research environments.
Product Specifications
- Molecular Formula
- C₁₄H₂₂N₄O₉
- Molecular Weight
- 390.35 g/mol
- CAS #
- 307297-39-8
- Sequence
- Ala-Glu-Asp-Gly
- Purity
- ≥99% (HPLC verified)
- Form
- Lyophilized powder
- Appearance
- White to off-white powder
- Solubility
- Universal Solvent
- Storage
- -20°C (lyophilized), 2-8°C (after preparation)
Reference
- Khavinson, V. K., & Morozov, V. G. (2003). Peptides of pineal gland and thymus prolong human life. Neuro Endocrinology Letters, 24(3–4), 233–240.
- Anisimov, V. N., Khavinson, V. K., Provinciali, M., et al. (2006). Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. International Journal of Cancer, 101(1), 7–10.
- Khavinson, V., Diomede, F., Mironova, E., et al. (2020). AEDG peptide (Epitalon) stimulates gene expression and protein synthesis during neurogenesis: Possible epigenetic mechanisms. Molecules, 25(3), 609.
